I would love some advice on head-to-tail cyclization methods for small synthetic
peptides.I am in the process of synthesizing my first cyclic peptide. This
particular peptide is very simple, a pentaGly, but I will be soon be
synthesizing more complex cyclic peptides. The peptide is currently on a
chlorotrityl resin. I am planning to cleave the peptide from the resin and then
cyclize, but I suppose I could try on-resin methods of cyclization.
Could you please enlighten me as to the most effective current cyclization
methods. Thank you in advance.
Kathy Schegg
University of Nevada, Reno
schegg@med.unr.edu
(775) 784-4058
(775) 784-1419 Fax