Arg-Pbf

Matteo Villain (villain@uab.edu)
Fri, 13 Aug 1999 09:48:33 -0500

For the peptide chemist.
I have a problem with the cleavege of a tetrameric MAPS. It contain a
total of 8 Arg (I used Fmoc-Arg(Pbf) ). I did it on a Perseptive PEG-PS
resin as an amide.
When I cleve it (reagent K), using ~5ml for 200 mg of resin, I found a
precipitate in the cleavege mixture. I'm not sure is the peptide, of if
the pbf group can precipitate in TFA.
Anyone with the same experience?
Matteo Villain

--
Matteo Villain                   E-mail : villain@uab.edu
Research Associate               Phone  : 205 934 3032
University of Alabama            Fax    : 205 934 1446
Birmingham
35294, USA