Cyanogen Bromide cleavage
Henry Keutmann (keutmann@helix.mgh.harvard.edu)
Fri, 13 Aug 1999 17:23:23 -0400
To the ABRF Roundtable--
Are there any examples of cyanogen bromide cleavage at residues
other than methionine--e.g. Leucine or (in a reduced protein) cysteine?
I've not found any myself but have been asked by a colleague who
suspects he may have obtained an anomalous cleavage under standard CNBr
reaction conditions.
Thanks for you help!
Henry T. Keutmann
Endocrine Unit
Mass. General Hospital
Boston MA 02114
617-726-3966