Loading ethanolamine to tritylchlorid resin

Surovoy A. (surovoy@ibch.siobc.ras.ru)
Tue, 19 Oct 1999 19:13:31 +0400

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Hi All!
I've got a trouble with loadingö N-Fmoc-ethanolamine to Tritylchlorid
resin.
I use 4 eq. of alcohol, 4 eq of pyridine in THF for coupling, and high
temperature ( 60*C)
The max. substitution I got is 0.23 mmol/g

If somebody know what is the problem, or other method of loading.

Thanks
Andrejö

Next message: Theodore Thannhauser: "Staff Scientist"
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