pK1 pK2 pK-R pK-I
Amino acid COOH NH3 Rgrp
Glycine 2.34 9.6 - 5.97
Alanine 2.34 9.69 - 6.02
Leucine 2.36 9.60 - 5.98
Serine 2.21 9.15 - 5.68
Threonine 2.63 10.43 - 6.53
Glutamine 2.17 9.13 - 5.65
Aspartic Acid 2.09 9.82 3.86 2.98
Glutamic Acid 2.19 9.67 4.25 3.25
Histidine 1.82 9.17 6.0 7.59
Cysteine 1.71 8.33 10.78 5.25
Tyrosine 2.20 9.11 10.07 5.66
Lysine 2.18 8.95 10.53 9.74
Arginine 2.17 9.04 12.48 10.76
Sorry but I am not going to straighten these cols.
These are copied from Lehningerís ìBiochemistryî, p79
Worth Publishing 1975. I calculated the pKIs from the rest of the data.
Use at your own risk.
and
from the archives
http://www.abrf.org/archives/hmail/97005/0000.html
and http://www.abrf.org/archives/hmail/97005/0002.html
and http://www.abrf.org/archives/hmail/97005/0020.html
Matt Sweeney
mattsweeney@earthlink.net
Mass Spec Consulting
Training/Operations/Consulting/Method Development
LC/MS Pharmacokinetics, Peptides, Proteins, Metabolism,
Maintenance Classes, Specialist in Finnigan Equipment and Software
-----Original Message-----
From: Christi <chrab@iusb.edu>
To: Recipients of ABRF List <abrf@aecom.yu.edu>
Date: Tuesday, September 14, 1999 11:08 AM
Subject: pKa for side chains of AA
>Is there a source book to find out pKa's for all of the amino acids?
>I stumbled across this email address while searching for "pKa", so I am
>not a member of this list...please email me directly at chrab@iusb.edu
>
>if anyone could forward me information about this list, what is is, how
>to subscribe, I would appreciate it very much!
>
>Thanks,
>Christi
>
>