You need to make your peptide with an orthogonally protected Glu residue if
you want to selectively deprotect - something like Fmoc-Glu(Dmab)-OH, where
you can take off the Dmab with 2% hydrazine in DMF.
Cheers,
Roger
At 11:33 03/11/99 -0500, you wrote:
>Hi,
>
>Need protocols to selectively deprotect one of the Glu in a fully protected
>peptide. Thanks.
>
>
>Bob
------------------------------------------------------------
Roger Murphy, Ph.D.
Biological Production Facility
Ludwig Institute for Cancer Research
Austin & Repatriation Medical Centre
Studley Road,
Heidelberg, Vic. 3084
Australia.
Tel 61-3-94965463
Fax 61-3-94965436
Email Roger.Murphy@Ludwig.edu.au