RE: IE HPLC - embarassing conclusion

Chin, David T. (ChinD@missouri.edu)
Fri, 3 Dec 1999 09:56:02 -0600

Jenny,
Thank you very much for your report on the final outcome. There's
lots of good suggestions on the board, but it's very helpful to find out the
final solution(s) and trouble shooting areas.

David.

David T. Chin
Director, Protein Core Facility
Protein Chemistry and Expression
2-17 Agriculture Building
Univ. of Missouri - Columbia
Columbia, MO 65211-7170

SHIPPING AND ACTUAL LOCATION:
2-17 Agriculture Building (office)
2-31 Agriculture Building (Lab)

e-Mail: chind@missouri.edu
web: http://www.biotech.missouri.edu/pc
[mailto:chind@missouri.edu]
Phone: 573-882-2027
Fax: 573-882-7105

-----Original Message-----
From: Jenny Shipway [mailto:jennys@biols.susx.ac.uk]
Sent: Friday, December 03, 1999 5:01 AM
To: Recipients of ABRF List
Subject: Re: IE HPLC - embarassing conclusion

I thought it was all a bit odd...

I now know what the problem was, it was a bad case of eye-brain
miscoordination. Yes, I am now blushing heartily as I admit that, just
upstream of my lovely new IE column, I still had the RP guard column
plumbed in. Arragghhhh! My only excuse is that I thought the thing just
had filters in, which is a bit of a crap excuse, I admit. My only
consolations are that nobody else in the lab spotted it either, reducing
their rights to laugh mercilessly at me, and that I guess the IE column is
fine after all (haven't had a chance to check it out yet). The worst thing
(but also the way I worked it out) was that the person using the system
after me had to spend all of yesterday cleaning my junk out of it - ooops.
Luckily he was too busy laughing at me to hit me.

Sorry for being such a dunce, but thanks for all your many replies - I
now know a million times more about such things than I used to, anyway. I
will now crawl back into the woodwork and write out one thousand times
"Guard columns bind peptide".

Yours embarrassedly,

Jenny