| Metabolomics Research Group (MRG) |
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Current Members |
Studies |
Activities |
Protocols |
Membership History |
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| Welcome to the new 'Metabolomics Research Group' of the ABRF. The MRG was formed in March of 2009 and has now announced its first 'Research Study'. |
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| Metabolomics is the comprehensive profiling of metabolites and other small molecules. The large structural diversity of these compounds makes both comprehensive profiling and identification challenging. The major platforms are NMR and mass spectrometry, particularly LC/MS and GC/MS. There is currently a great variety of approaches, including untargeted profiling, targeted approaches, and fluxomics. Both semi-quantitative and quantitative approaches can be used. Challenges include identification of metabolites and how they change in relation to a biological perturbation (e.g. drug, diet, disease) and determining the biological significance of these changes.
The Metabolomics Research Group consists of members from academic core and research laboratories, industrial analytical laboratories and providers of metabolomic services, analytical standards and instrumentation. The immediate aim of the Metabolomics Research Group is a) to educate research scientists and resource facilities in the analytical approaches and management of data resulting from comprehensive metabolite studies and b) to promote the science and standardization of metabolomic analyses for a variety of applications. Short term efforts of the group will include conducting surveys and organizing sessions at the annual ABRF meeting to explore the current state of the art in the field. Further activities will include the organization of research studies. |
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| Current Membership |
Dr. William R. Wikoff
(Chair) - University of California, Davis
Dr. Pavel Aronov
- Stanford University
Dr. John M Asara
- Beth Israel Deaconess Medical Center
Dr. Amrita K. Cheema
- Georgetown University
Prof. Vladimir Shulaev
- University of North Texas
Dr. Vladimir V. Tolstikov
- UC Davis Genome Center
Chris W Turck
(Ad hoc) - Max Planck Institute of Psychiatry
Dr. Brett S Phinney
(EB liaison) - Proteomics Core UC Davis Genome Center
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| Studies |
| 1) |
The Metabolomics Research Group invites interested laboratories to participate in its first Research Study. Please check the attached announcement letter for more details.
- View Document
(125K)
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| 2) |
The MRG has conducted a survey to collect data on the current use of metabolomics technologies in core facilities.
Questions were designed to elicit responses concerning the current level of interest in the field of metabolomics, and for those already offering a metabolomics service to find out what instrumentation is used, types of application, etc.
The results of the survey were presented at the ABRF2010 meeting during the MRG session.
- View Document
(146K)
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| Activities |
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MRG members Bill Wikoff, Vladimir Tolstikov and John Asara presented details on ongoing MRG Study, metabolomics core laboratories and research projects.
- Bill Wikoff Presentation
- Vladimir Tolstikov Presentation
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| 2) |
William Wikoff of the MRG organized a Satellite Workshop entitled 'An Introduction to Metabolomics' at ABRF2011. The workshop was intended for the scientist who wants an introduction to metabolomics, with an emphasis on practical, mass spectrometry-based approaches. The entire process of metabolomics, from study design to data processing and analysis was presented. Topics included: types of detectors and their relative merits for specific metabolomics applications(including standard and specialized instruments), methods for sample extraction peak integration, data alignment, software, and data analysis with an emphasis on selecting straightforward approaches appropriate for a given problem. Approaches to biomarker discovery and metabolomics in drug discovery were discussed and a review of selected case studies from the literature were included.
- ABRF2011 Satellite Workshop
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| 3) |
The newly formed 'Metabolomics Research Group' held its first session at ABRF2010. Presentation topics included survey results and metabolomics core facilities.
- Chris Turck Presentation
- Tom O'Connell Presentation
(3,731K)
- Pavel Aronov Presentation
(628K)
- Vladimir Tolstikov Presentation
(2,608K)
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| 4) |
Bill Wikoff (MRG chair) organized the ‘Metabolomics Scientific Session’ at ABRF2010. Three prominent scientists in the field spoke about technolgies and applications.
- Bill Wikoff Presentation
- Oliver Fiehn Presentation
- David Wishart Presentation
- Chris Beecher Presentation
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| Protocols |
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| Membership History |
| Member Name |
Organization |
Details |
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Dr. Nathan Dodder |
NIST |
Member:
03/09 -
03/10
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Dr. Brenda Kesler |
Thermo Fisher Scientific |
Member:
03/09 -
02/11
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Dr Thomas M. O'Connell |
University of North Carolina |
Member:
03/09 -
11/10
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Chris W Turck |
Max Planck Institute of Psychiatry |
EB Liaison:
03/10 -
02/11
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Dr. William R. Wikoff |
University of California, Davis |
Member:
03/09 -
03/10
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