A database of protein post Translational modifications
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Average Masses
Avg. Mass Change | Modification |
---|---|
-79 | 5' dephospho |
-58 | Desmosine (from Lysine) |
-48 | decomposed carboxymethylated Methionine |
-44 | Decarboxylation of gamma carboxy Glutamate |
-43 | Gamma-glutamyl semialdehyde (from arginine) |
-42 | Ornithine (from Arginine) |
-34 | Lysinoalanine (from Cysteine) |
-34 | Lanthionine (from Cysteine) |
-34 | Dehydroalanine (from Cysteine) |
-30 | Homoserine formed from Met by CNBr treatment |
-27 | Oxidation of arginine (to glutamic acid) |
-18 | Formylglycine (from cysteine) |
-18 | Pyroglutamic Acid formed from Glutamic Acid |
-18 | Dehydration (-H2O) |
-18 | S-gamma-Glutamyl (crosslinked to Cysteine) |
-18 | O-gamma-Glutamyl- (Crosslink to Serine) |
-18 | Serine to Dehydroalanine |
-18 | Alaninohistidine (Serine crosslinked to theta or pi carbon of Histidine) |
-18 | Misincorporation of Norleucine for Methionine |
-18 | Succinimide formation from aspartic acid |
-17 | Pyroglutamic Acid formed from Gln |
-17 | N-pyrrolidone carboxyl (N terminus) |
-17 | N alpha -(gamma-Glutamyl)-lysine |
-17 | N-(beta-Aspartyl)-Lysine (Crosslink) |
-17 | Succinimide formation from asparagine |
-17 | S-carbamoylmethylcysteine cyclization (N-terminus) |
-16 | Pyruvoyl- (Serine) |
-5 | Crosslink between Arg and His sidechains |
-4 | 3,3',5,5'-TerTyr (Crosslink) |
-2 | Formylglycine (from serine) |
-2 | Disulphide bond formation (Cystine) |
-2 | S-(2-Histidyl)- (Crosslinked to Cysteine) |
-2 | S-(3-Tyr) (Crosslinked to Cysteine) |
-2 | 3,3'-BiTyr (Crosslink) |
-2 | IsodiTyr (Crosslink) |
-1 | Allysine (from Lysine) |
-1 | Amide formation (C terminus) |
-1 | Oxidation of lysine (to aminoadipic semialdehyde) |
1 | Deamidation of Asparagine and Glutamine to Aspartate and Glutamate |
1 | Citruline (from Arginine) |
2 | ysteine x2, reduction of Cystine (Cys-Cys) |
2 | Reduction of indole double bond of Trp |
4 | Oxidation of Trp to kynurenine |
12 | Lysine epsilon amino to imine |
12 | Cysteine (N-term) formaldehyde adduct (Cys to Thioproline conversion) |
12 | Formaldehyde adduct of Trp |
13 | Syndesine (from Lysine) |
13 | CM-Cys vs PAM-Cys |
14 | Methylation (N terminus, N epsilon of Lysine, O of Serine, Threonine or C terminus, N of Asparagine) |
14 | CAM-Cys vs PAM-Cys |
14 | Methylation (methyl esterification of Asp and Glu side chains) |
15 | Delta-Hydroxy-allysine (from Lysine) |
15 | Oxidation of lysine (to aminoadipic acid) |
16 | Hydroxylation (of delta C of Lysine, beta C of Tryptophan, C3 or C4 of Proline, beta C of Aspartate) |
16 | Oxidation of Methionine (to Sulphoxide) |
16 | 3,4-Dihydroxy-Phenylalanine (from Tyrosine) (DOPA) |
16 | Oxohistidine (from histidine) |
16 | Sulfenic Acid (from Cysteine) |
16 | Oxidation of proline (to gamma-glutamyl semialdehyde) |
22 | Sodium |
28 | Ethyl |
28 | N,N dimethylation (of Arginine or Lysine) |
28 | 2,4-BisTrp-6,7-dione (from Tryptophan) |
28 | Formylation (CHO) |
30 | 6,7 Dione (from Tryptophan) |
32 | 3,4,6-Trihydroxy-Phenylalanine (from Tyrosine) (TOPA) |
32 | 3,4-Dihydroxylation (of Proline) |
32 | Oxidation of Methionine (to Sulphone) |
32 | Oxidation of proline (to glutamic acid) |
32 | Double oxidation of Trp |
32 | Trisulfide bond (additional sulfur in disulfide bond) |
34 | 3-Chlorination (of Tyrosine with 35Cl) |
36 | 3-Chlorination (of Tyrosine with 37Cl) |
38 | Potassium |
42 | Acetylation (N terminus, N epsilon of Lysine, O of Serine) (Ac) |
42 | N-Trimethylation (of Lysine) |
43 | Carbamylation |
44 | disodium |
45 | Nitro (NO2) |
46 | beta-Methylthio-aspartic acid |
48 | Cysteic acid, oxidation of cysteine |
51 | Piperidine adduct to C-terminal Cys |
56 | t-butyl ester(OtBu) and t-butyl (tBu) |
57 | Glycyl (-G-,-Gly-) |
57 | Carboxamidomethyl (on Cysteine and other residues) |
58 | Carboxymethyl (on Cysteine and other residues) |
60 | sodium + potassium |
64 | Selenocysteine (from Serine) |
67 | Asp transamidation with piperidine |
68 | 3,5-Dichlorination (of Tyrosine with 35Cl) |
69 | Dehydroalanine (Dha) |
70 | 3,5-Dichlorination (of Tyrosine with mixture of 35Cl and 37Cl)) |
70 | Pyruvate |
71 | Sarcosyl |
71 | Alanyl (-A-, -Ala-) |
71 | Acetamidomethyl (Acm) |
71 | Propionamide or Acrylamide adduct |
72 | 3,5-Dichlorination (of Tyrosine with 37Cl) |
74 | S-(sn-1-Glyceryl) (on Cysteine) |
74 | Glycerol Ester (on Glutamic acid side chain) |
75 | Glycine (G, Gly) |
76 | Phenyl ester (OPh) (on acidic) |
76 | Beta mercaptoethanol adduct |
78 | 3-Bromination (of Tyrosine with 79Br) |
78 | 3-o-bromination of Phe with 79Br |
80 | L-o-bromination of Phe with 81Br |
80 | Sulphonation (SO3H) (of PMC group) |
80 | Sulphation (of O of Tyrosine) |
80 | Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine) |
80 | 3-Bromination (of Tyrosine with 81Br) |
82 | Cyclohexyl ester (OcHex) |
83 | Homoseryl lactone |
83 | Homoseryl lactone |
85 | 2-Aminobutyric acid (Abu) |
85 | 2-Aminoisobutyric acid (Aib) |
85 | Gamma Aminobutyryl |
86 | t-butyloxymethyl (Bum) |
86 | Diaminopropionyl |
87 | N-(4-NH2-2-OH-butyl)- (of Lysine) (Hypusine) |
87 | Seryl (-S-, -Ser-) |
88 | t-butylsulfenyl (StBu) |
89 | Alanine (A, Ala) |
89 | Sarcosine (Sar) |
90 | Anisyl |
90 | Benzyl (Bzl) and benzly ester (OBzl) |
93 | 1,2-ethanedithiol (EDT) |
95 | Dehydroprolyl |
96 | Trifluoroacetyl (TFA) |
97 | N-hydroxysuccinimide (ONSu, OSu) |
97 | Prolyl (-P-, -Pro-) |
98 | Cysteic acid x2, oxidation of cystine |
98 | Tetramethylguanidinium termination by-product on amine |
98 | Phosphate/sulphate adduct of proteins |
99 | Valyl (-V-, -Val-) |
99 | Isovalyl (-I-,-Iva-) |
100 | t-Butyloxycarbonyl (tBoc) |
101 | Threoyl (-T-, -Thr-) |
101 | Homoseryl (-Hse-) |
103 | Cystyl (-C-, -Cys-) |
104 | 4-Methylbenzyl (Meb) |
104 | Benzoyl (Bz) |
105 | Serine (S, Ser) |
105 | Pyridylethylation of cysteine |
106 | HMP (hydroxymethylphenyl) linker |
106 | Thioanisyl |
106 | Thiocresyl |
111 | 2-Piperidinecarboxylic acid (Pip) |
111 | Pyroglutamyl |
113 | Hydroxyprolyl (-Hyp-) |
113 | Isoleucyl (-I-, -Ile-) |
113 | Leucyl (-L-, -Leu-) |
113 | Norleucyl (-Nle-) |
114 | Asparagyl (-N-, -Asn-) |
114 | t-amyloxycarbonyl (Aoc) |
114 | Ornithyl (-Orn-) |
115 | Proline (P, Pro) |
115 | Aspartyl (-D-, -Asp-) |
117 | Succinyl |
117 | Valine (V, Val) |
117 | Hydroxybenzotriazole ester (HOBt) |
118 | Dimethylbenzyl (diMeBzl) |
119 | Threonine (T, Thr) |
119 | Cysteinylation |
120 | Benzyloxymethyl (Bom) |
120 | p-methoxybenzyl (Mob, Mbzl) |
121 | 4-Nitrophenyl, p-Nitrophenyl (ONp) |
121 | Cysteine (C, Cys) |
125 | Chlorobenzyl (ClBzl) |
126 | Iodination (of Histidine[C4] or Tyrosine[C3]) |
126 | octanoylation |
128 | Glutamyl (-Q-, -Gln-) |
128 | Lysyl (-K-, -Lys-) |
129 | Glutamyl (-E-, -Glu-) |
129 | O-Methyl Aspartamyl |
130 | N alpha -(gamma-Glutamyl)-Glu |
131 | Norleucine (Nle) |
131 | Hydroxyproline (Hyp) |
131 | Isoleucine (I, Ile) |
131 | Leucine (L, Leu) |
131 | Methionyl (-M-, -Met-) |
131 | Hydroxy Aspartamyl |
131 | bb-dimethyl Cystenyl |
132 | Asparagine (N, Asn) |
132 | Pentoses (Ara, Rib, Xyl) |
133 | Aspartic Acid (D, Asp) |
134 | Benzyloxycarbonyl (Z) |
134 | Adamantyl (Ada) |
135 | p-Nitrobenzyl ester (ONb) |
137 | Histidyl (-H-, -His-) |
142 | N-methyl Glutaminyl |
142 | N-methyl Lysyl |
143 | O-methyl Glutamyl |
143 | Diphthamide (from Histidine) |
144 | Hydroxy Lysyl (-Hyl-) |
145 | Methyl Methionyl |
146 | Glutamine (Q, Gln) |
146 | Deoxyhexoses (Fuc, Rha) |
146 | Lysine (K, Lys) |
146 | Pentosyl |
146 | Aminoethyl Cysteinyl (AECys) |
147 | 4-Glycosyloxy- (pentosyl,C5) (of Proline) |
147 | Glutamic Acid (E, Glu) |
147 | Phenylalanyl- (-F-, -Phe-) |
147 | Methionyl Sulfoxide |
148 | Pyridyl Alanyl |
149 | 2-Nitrobenzoyl (NBz) |
149 | Methionine (M, Met) |
149 | Fluorophenylalanyl |
150 | Dimethoxybenzyl Trp |
153 | 2-Nitrophenylsulphenyl (Nps) |
154 | 4-Toluenesulphonyl (Tosyl, Tos) |
154 | 3-nitro-2-pyridinesulfenyl (Npys) |
155 | Histidine (H, His) |
156 | 3,5-Dibromination (of Tyrosine with 79Br) |
156 | Arginyl (-R-, -Arg-) |
157 | Citrulline |
158 | 3,5-Dibromination (of Tyrosine with mixture of 79Br and 81Br) |
159 | Dichlorobenzyl (Dcb) |
160 | 3,5-Dibromination (of Tyrosine with 81Br) |
160 | Carboxyamidomethyl Cystenyl |
161 | Hexosamines (GalN, GlcN) |
161 | Carboxymethyl cysteine (Cmc) |
161 | Carboxymethyl Cystenyl |
161 | Methylphenylalanyl |
162 | Inositol |
162 | N-Glucosyl (N terminus or N epsilon of Lysine) (Aminoketose) |
162 | O-Glycosyl- (to Serine or Threonine) |
162 | Linker attached to peptide in Fmoc peptide synthesis |
162 | Hexoses (Fru, Gal, Glc, Man) |
163 | Tyrosinyl (-Y-, -Tyr-) |
163 | MethionylSulphone |
165 | Phenylalanine (F, Phe) |
166 | 2,4 -dinitrophenyl (Dnp) |
166 | Pentaflourophenyl (Pfp) |
166 | Diphenylmethyl (Dpm) |
167 | Phospho Seryl |
169 | 2-Chlorobenzyloxycarbonyl (ClZ) |
169 | Napthyl acetyl |
170 | N-acetyl Lysyl |
170 | N-methyl Arginyl |
170 | Decanoic acid modification of Cys in active site |
172 | Ethanedithiol/TFA cyclic adduct |
173 | Carboxy Glutamyl (Gla) |
174 | Arginine (R, Arg) |
174 | Acetamidomethyl Cystenyl |
174 | Acrylamidyl Cystenyl |
176 | N-Glucuronyl (N terminus) |
177 | delta-Glycosyloxy- (of Lysine) or beta-Glycosyloxy- (of Phenylalanine or Tyrosine) |
177 | 4-Glycosyloxy- (hexosyl,C6) (of Proline) |
177 | Benzyl Seryl |
177 | N-methyl Tyrosinyl |
178 | a-N-Gluconoylation (His Tagged proteins) |
179 | p-Nitrobenzyloxycarbonyl (4Nz) |
179 | 2,4,5-Trichlorophenyl |
180 | 2,4,6-trimethyloxybenzyl (Tmob) |
180 | Xanthyl (Xan) |
181 | Tyrosine (Y, Tyr) |
182 | Chlorophenylalanyl |
182 | Mesitylene-2-sulfonyl (Mts) |
183 | AEBSF |
184 | Isopropyl Lysyl |
186 | Tryptophanyl (-W-, - Trp-) |
186 | Carboxymethyl Lysyl |
188 | N-Lipoyl- (on Lysine) |
190 | Matrix alpha cyano MH+ |
191 | Benzyl Threonyl |
193 | Benzyl Cystenyl |
197 | Napthyl Alanyl |
198 | Succinyl Aspartamyl |
201 | HMP (hydroxymethylphenyl)/TFA adduct |
203 | N-acetylhexosamines (GalNAc, GlcNAc) |
204 | Tryptophan (W, Trp) |
204 | Cystine ((Cys)2) |
204 | Farnesylation |
206 | S-Farnesyl- |
206 | Myristoylation-4H (2 double bonds) |
208 | Myristoleylation (myristoyl with one double bond) |
208 | Pyridylethyl Cystenyl |
210 | Myristoylation |
212 | 4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) |
213 | 2-Bromobenzyloxycarbonyl (BrZ) |
214 | Formyl Tryptophanyl |
219 | Benzyl Glutamyl |
219 | Anisole Adducted Glutamyl |
222 | 9-Fluorenylmethyloxycarbonyl (Fmoc) |
222 | S-cystenyl Cystenyl |
226 | Biotinylation (amide bond to lysine) |
226 | Dimethoxybenzhydryl (Mbh) |
229 | N-Pyridoxyl (on Lysine) |
231 | Pyridoxal phosphate (Schiff Base formed to lysine) |
233 | Dansyl (Dns) |
233 | Nicotinyl Lysyl |
238 | 2-(p-biphenyl)isopropyl-oxycarbonyl (Bpoc) |
238 | Palmitoylation |
242 | Triphenylmethyl (Trityl, Trt) |
243 | Tyrosinyl Sulphate |
243 | Phospho Tyrosinyl |
252 | Pbf (pentamethyldihydrobenzofuransulfonyl) |
252 | 3,5-Diiodination (of Tyrosine) |
258 | a-N-6-Phosphogluconoylation (His Tagged proteins) |
259 | N alpha -(gamma-Glutamyl)-Glu2 |
266 | Stearoylation |
266 | Pmc (2,2,5,7,8- Pentamethylchroman-6-sulphonyl) |
272 | Geranylgeranylation |
272 | Monomethoxytrityl |
276 | S-Geranylgeranyl |
283 | O-GlcNAc-1-phosphorylation (of Serine) |
289 | 5'phos dCytidinyl |
289 | iodo Tyrosinyl |
290 | Aldohexosyl Lysyl |
291 | Sialyl |
291 | N-acetylneuraminic acid (Sialic acid, NeuAc, NANA, SA) |
304 | 5'phos dThymidinyl |
305 | 5'phos Cytidinyl |
305 | Glutathionation |
306 | O-Uridinylylation (of Tyrosine) |
306 | 5'phos Uridinyl |
307 | N-glycolneuraminic acid (NeuGc) |
307 | S-farnesyl Cystenyl |
313 | 5'phos dAdenosyl |
324 | O-pantetheinephosphorylation (of Serine) |
327 | SucPhencarb Lysyl |
329 | 5'phos dGuanosyl |
329 | 5'phos Adenosinyl |
329 | O-5'-Adenosylation ( of Tyrosine) |
339 | 4'-Phosphopantetheine |
342 | S-palmityl Cystenyl |
345 | 5'phos Guanosyl |
354 | Biotinyl Lysyl |
359 | Fluorescein labelling of peptide N-terminal using NHS ester |
365 | Hex-HexNAc |
388 | N alpha -(gamma-Glutamyl)-Glu3 |
391 | Dioctyl Phthalate |
395 | PMC Lysyl |
409 | Aedans Cystenyl |
413 | Dioctyl Phthalate Sodium Adduct |
415 | di-iodo Tyrosinyl |
423 | PMC Arginyl |
454 | S-Coenzyme A |
457 | AMP Lysyl |
470 | 3,5,3'-Triiodothyronine (from Tyrosine) |
524 | S-(sn-1-Dipalmitoyl-glyceryl)- (on Cysteine) |
541 | S-(ADP-ribosyl)- (on Cysteine) |
541 | N-(ADP-ribosyl)- (on Arginine) |
541 | O-ADP-ribosylation (on Glutamate or C terminus) |
541 | ADP-rybosylation (from NAD) |
617 | S-Heme (on Cysteine) |
648 | N theta -(ADP-ribosyl) diphthamide (of Histidine) |
657 | NeuAc-Hex-HexNAc |
783 | O-8 alpha-Flavin [FAD])- (of Tyrosine) |
784 | S-(6-Flavin [FAD])- (on Cysteine) |
784 | N theta and N pi-(8alpha-Flavin) (on Histidine) |
893 | (Hex)3-HexNAc-HexNAc |
1,039 | (Hex)3-HexNAc-(dHex)HexNAc |